Teghanemt A, Misel-Wuchter K, Heath J, Thurman A, Pulipati P, Dixit G, Geesala R, Meyerholz D, Maretzky T, Pezzulo A, Issuree PD. DNA demethylation fine-tines IL-2 production during thymic regulatory T cell differentiation. EMBO Reports. 2023. https://doi.org/10.15252/embr.202255543 

Dixit G, Gonzalez-Bosquet, Skurski J, Devor EJ, Dickerson EB, Nothnick WB, Issuree PD, Leslie KK, Maretzky T. FGFR2 mutations promote endometrial cancer progression through dual engagement of EGFR and Notch signaling pathways. ClinTransMed. 2023 (Accepted)


Teghanemt A, Pulipati P*, Misel-Wuchter K*, Day K, Yorek MS, Yi R, Keen HL Au C, Maretzky T, Gurung P, Littman DR, Issuree PD. CD4 expression in effector T cells depends on DNA demethylation over a developmentally established stimulus-responsive element. Nat Commun.2022 Feb 16. 10.1038/s41467-022-28914-4


Skurski J, Dixit G, Blobel CP, Issuree PD*, Maretzky T*. The Threshold Effect: Lipopolysaccharide-Induced Inflammatory Responses in Primary Macrophages Are Differentially Regulated in an iRhom2-Dependent Manner. Front Cell Infect Microbiol. 2021 Jan 29;10:620392.doi: 10.3389/fcimb.2020.620392. eCollection 2020.


Skurski J, Penniman CM, Geesala R, Dixit G, Pulipati P, Bhardwaj G, Meyerholz DK, Issuree PD, O'Neill BT, Maretzky T.Loss of iRhom2 accelerates fat gain and insulin resistance in diet-induced obesity despite reduced adipose tissue inflammation.Metabolism. 2020 Mar 2:154194. doi: 10.1016/j.metabol.2020.154194. [Epub ahead of print]


Geesala R, Issuree PD, Maretzky T. Novel functions of inactive rhomboid proteins in immunity and disease. J Leukoc Biol.2019 Oct;106(4):823-835. doi: 10.1002/JLB.3VMR0219-069R. Epub 2019 Aug 1. Review. PubMed PMID: 31369701.

Geesala R, Schanz W, Biggs M, Dixit G, Skurski J, Gurung P, Meyerholz DK, Elliott D, Issuree PD, Maretzky T. Loss of RHBDF2 results in an early-onset spontaneous murine colitis. J Leukoc Biol. 2019 Apr;105(4):767-781. doi: 10.1002/JLB.4A0718-283RR. Epub 2019 Jan 29. PubMed PMID: 30694569; PubMed Central PMCID: PMC6585405.


Issuree PD, Day K, Au C, Raviram R, Zappile P, Skok JA, Xue HH, Myers RM, Littman DR. Stage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development. Nat Commun. 2018 Sep 5;9(1):3594. doi: 10.1038/s41467-018-05834-w. PubMed PMID: 30185805; PubMed Central PMCID: PMC6125341.

Qing X, Chinenov Y, Redecha P, Madaio M, Roelofs JJ, Farber G, Issuree PD, Donlin L, Mcllwain DR, Mak TW, Blobel CP, Salmon JE. iRhom2 promotes lupus nephritis through TNF-α and EGFR signaling. J Clin Invest. 2018 Apr 2;128(4):1397-1412. doi: 10.1172/JCI97650. Epub 2018 Mar 5. PubMed PMID: 29369823; PubMed Central PMCID: PMC5873859.


Issuree PD, Ng CP, Littman DR. Heritable Gene Regulation in the CD4:CD8 T Cell Lineage Choice. Front Immunol. 2017;8:291. doi:10.3389/fimmu.2017.00291. eCollection 2017. Review. PubMed PMID: 28382035; PubMed Central PMCID: PMC5360760.


Qing X, Rogers L, Mortha A, Lavin Y, Redecha P, Issuree PD, Maretzky T, Merad M, McIlwain D, Mak TW, Overall CM, Blobel CP, Salmon JE. iRhom2 regulates CSF1R cell surface expression and non-steady state myelopoiesis in mice. Eur J Immunol. 2016 Dec;46(12):2737-2748. doi: 10.1002/eji.201646482. Epub 2016 Sep 28. PubMed PMID: 27601030; PubMed Central PMCID: PMC5149455.


Sellars M, Huh JR, Day K, Issuree PD, Galan C, Gobeil S, Absher D, Green MR, Littman DR. Regulation of DNA methylation dictates Cd4 expression during the development of helper and cytotoxic T cell lineages. Nat Immunol. 2015 Jul;16(7):746-54. doi: 10.1038/ni.3198. Epub 2015 Jun 1. PubMed PMID: 26030024; PubMed Central PMCID: PMC4474743.

Li X, Maretzky T, Weskamp G, Monette S, Qing X, Issuree PD, Crawford HC, McIlwain DR, Mak TW, Salmon JE, Blobel CP.iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling. Proc Natl Acad Sci U S A. 2015 May 12;112(19):6080-5. doi: 10.1073/pnas.1505649112. Epub 2015 Apr 27. PubMed PMID: 25918388; PubMed Central PMCID: PMC4434755.


Maretzky T, McIlwain DR, Issuree PD, Li X, Malapeira J, Amin S, Lang PA, Mak TW, Blobel CP. iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11433-8. doi: 10.1073/pnas.1302553110. Epub 2013 Jun 25. PubMed PMID: 23801765; PubMed Central PMCID: PMC3710827.

Issuree PD, Maretzky T, McIlwain DR, Monette S, Qing X, Lang PA, Swendeman SL, Park-Min KH, Binder N, Kalliolias GD, Yarilina A, Horiuchi K, Ivashkiv LB, Mak TW, Salmon JE, Blobel CP. iRHOM2 is a critical pathogenic mediator of inflammatory arthritis. J Clin Invest. 2013 Feb;123(2):928-32. doi: 10.1172/JCI66168. Epub 2013 Jan 25. PubMed PMID: 23348744; PubMed Central PMCID: PMC3561822.

Le Gall SM, Maretzky T, Issuree PD, Niu XD, Reiss K, Saftig P, Khokha R, Lundell D, Blobel CP. ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site. J Cell Sci. 2010 Nov 15;123(Pt 22):3913-22. doi: 10.1242/jcs.069997. Epub 2010 Oct 27. PubMed PMID: 20980382; PubMed Central PMCID: PMC2972273.